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Atrioventricular block, intraventricular conduction disturbances, cardiogenic shock, and asystole may occur with severe overdose, especially with membrane-depressant drugs eg, propranolol. The metabolism of lidocaine is inhibited by co-administration of propranolol, resulting in 25 increase in lidocaine concentrations. Clinical Studies In series of 225 patients with supraventricular 145 ventricular 69 or both 11 arrythmias resistant to digitalis, intravenous Propranolol hydrochloride was administered in single doses, averaging to mg. Chronic renal failure has been associated with decrease in drug metabolism via downregulation of online propranolol cumpar hepatic cytochrome P450 activity resulting in lower clearance. Beta-blockers are ineffective in the treatment of pure vasospastic Prinzmetal angina.

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