In 2-year study in mice fed pravastatin at doses of 250 and 500 mg kg day, there was an increased incidence of hepatocellular carcinomas in males and females at both 250 and 500 mg kg day. The AUC of pravastatin tended to increase, but the overall bioavailability of pravastatin plus its metabolites SQ 31,906 and SQ 31,945 was not altered. Effects of Lipid Lowering by Pravastatin on Progression and Regression of Coronary Artery Disease in Symptomatic Man With Normal to Moderately Elevated Serum Cholesterol Levels. If it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. It belongs to class of drugs called HMG-CoA reductase Inhibitors, commonly called statins. Pravastatin undergoes extensive first-pass extraction in the liver extraction ratio. It is pravastatin med postforskott also used to slow blood vessel blockage and to reduce the need for medical procedures to open blocked blood vessels.